NEUMANN, HANS-GEORG,KLINKENBERG, ERNST-DIETER,SCHAUER, FRIEDER,LINDEQUIST, ULRIKE,JUELICH, WOLF-DIETER,MIKOLASCH, ANNETT,MANDA, KATRIN
申请号：
CA2640771
公开号：
CA2640771C
申请日:
2007.02.09
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention relates to a reabsorbable bone replacement material made ofcalcium phosphate particles of different phases which are embedded in aninventive-specific cross-linked collagen matrix. The aim of the invention isto form a non-brittle, bone replacement moulded body having a positive fit,i.e. having a shape which is anatomic and/or correspondes to the defect, whichperfectly fills the bone defect and can be reabsorbed thereby. Said aim isachieved by producing the bone replacement material made of a mixture ofcalcium phosphate particles which is embedded in an inventive cross-linkedcollagen matrix. In particular, the collagen cross-linking is achieved by aLaccase-induced peptide cross-linking and suitable bridge molecules.Essentially substituted dihydroxyarmotes and/or substrates of the lignolyticpolyphenoloxidases, such as Laccases, are suitable as bridge molecules. Also,monocyclic ortho-dihydroxyaromates, monocyclic para-dihydroxyaromates,bicyclic monohydroxyaromates, polycyclisc monohydroxyaromates, bicyclicdihydroxyaromates, polycyclic dihydroxyaromates, bicyclic trihydroxyaromates,polycyclic trihydroxyaromates, or mixtures thereof are used. The inventivehydroxyaromates are not part of a polymer chain as opposed to the knownconchal adhesive.
