HELGE B BODO,DANIELA REIMER,ANNA VENNERI,FRIEDERIKE NOLLMANN
申请号：
GB201215431
公开号：
GB2505448A
申请日:
2012.08.30
申请国别(地区):
GB
年份:
2014
代理人:
摘要：
The invention relates to non-ribosomal peptides isolated from ontamopathogenic bacteria which have antibiotic activities against protozoan parasites wherein said peptides comprise a C terminal amine group. This group may be as a phenylethylamine, agmatine or tryptamne amino acid. Furthermore, the invention provides novel gene clusters which encode for the non-ribosomal peptide synthetases (NRPS) that mediate the biochemical synthesis of the inventive peptides. The peptides provided by the invention fall under the categories Xenortides, Rhabdopeptides and Mevalagmapeptides. Their use in medicine, specifically in the treatment of a disease caused by a protozoan parasite, such as malaria or sleeping sickness； and/or as insecticidals, for example in plant protection agents is disclosed. Furthermore provided are methods for the production of the peptides of the invention, and the enzymes and. nucleic acids useful for their synthesis in a host cell.
