This invention relates to a hydroxy-tetrahydro-naphthalene or an ureaderivative formula (I) and salts thereof which are useful as activeingredients of pharmaceutical preparations, wherein A represents formula (II)or (III) wherein # represents the connection position to the molecule and Q1a,Q2a, Q3a and Q4a are defined, and E represents formula (IV) or (V) wherein #represents the connection position to the molecule and Q1b, Q2b, Q3b, Q4b,Q5b, R1b, na, ma, Xa and Ra are defined.