CHAPLEO, CHRISTOPHER BOURNE,克利斯朵夫柏尼恰普罗,克利斯朵夫柏尼恰普羅,HYDE, NEIL,尼尔海德,尼爾海德
申请号：
TW097106779
公开号：
TWI451868B
申请日:
2008.02.27
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
A composition, in parenteral unit dosage form or in a unit dosage form suitable for delivery via the dermis or mucosa, comprises buprenorphine and an amount of naloxone such that the ratio by weight of buprenorphine to naloxone delivered to or reaching the plasma of a patient is in the range of from 7.5:1 to 12.4:1. The analgesic action of the buprenorphine is potentiated by the low dose of naloxone, which also serves to reduce the likelihood of abuse of the composition by drug addicts. Also provided are a method of treatment of pain and the use of naloxone and buprenorphine for the manufactulre of a medicament.本發明提供一種組成物，為非腸胃道單位劑型或適合經由皮膚或黏膜遞送之單位劑型，此組成物包含丁丙諾非(buprenorphine)及一定量之納洛酮(naloxone)，以被遞送或到達病患血漿之丁丙諾非對納洛酮之重量比為7.5:1至12.4:1之範圍。丁丙諾非之止痛作用經低劑量納洛酮而加強，其亦提供降低此組成物被藥物成癮者濫用之或然率。亦提供者為一種治療疼痛之方法，及丁丙諾非與納洛酮用於製造醫藥之用途。
