The present invention relates to an MRI contrast agent comprising silica nanoparticles, and more specifically, to an MRI contrast agent comprising silica nanoparticles in which chelate is combined, and a manufacturing method thereof. According to the present invention, the MRI contrast agent is combined with chelate containing Fe 3+ or MN 2+ ion on silica nanoparticles with excellent water dispersibility, thereby having low toxicity compared to a commercialized contrast agent including Gd 3+. Also, the MRI contrast agent according to the present invention can be applied to T1-weighted MRI and T2-weighted MRI.COPYRIGHT KIPO 2015본 발명은 실리카 나노입자를 포함하는 자기공명영상 조영제에 관한 것이다. 보다 상세하게는, 본 발명은 킬레이트가 결합된 실리카 나노입자를 포함하는 자기공명영상 조영제, 그리고 이의 제조 방법에 대한 것이다.
