THE PRESENT INVENTION RELATES TO METHODS FOR A LONG-TERM AND SUSTAINED RELEASE OF FLAVONOIDS, IN PARTICULAR RHAMNOSE-CONTAINING FLAVONOIDS, AND FOR PROLONGING THE UPTAKE OF SAID FLAVONOIDS IN THE GASTRO-INTESTINAL TRACT. IT FURTHER RELATES TO COMPOSITIONS COMPRISING SAID FLAVONOID AND α-RHAMNOSIDASE. IT ALSO ENCOMPASSES COMPOSITIONS COMPRISING HESPERIDIN AND HESPERETIN-7-GLUCOSIDE.FIGURE 2