Provided is a compound useful as an AMPK activator.A compound represented by formula (I) or a pharmaceutically acceptable salt thereof.[In formula (I): L represents -NR1-, =N-, -O-, -S-, -SO2-, -CR2R3- or =CR2-； the broken line represents the presence or absence of a bond； X represents -CR4R5- or -O-； Y represents optionally substituted heteroaryl or optionally substituted heterocyclyl； Z represents =CR6- or =N-； R1 represents hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R2 and R3 independently represent hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R4 and R5 independently represent hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R6 represents hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R7, R8 and R9 independently represent hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R10 and R11 independently represent hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； and R12 represents hydrogen or optionally substituted alkyl.]La présente invention décrit un composé utile comme activateur de l'AMPK. Un composé représenté par la formule (I) ou son sel de qualité pharmaceutique. [Dans la formule (I) : L représente -NR1-, =N-, -O-, -S-, -SO2-, -CR2R3- ou =CR2- ； la ligne brisée représente la présence ou l'absence d'une liaison ； X représente -CR4R5- ou -O- ； Y représente un groupe hétéroaryle éventuellement substitué ou hétérocyclyle éventuellement substitué ； Z r
