SPIEGELMAN, BRUCE M.,PUIGSERVER, PERE,WU, ZHIDAN,ADELMANT, GUILLAUME
申请号：
CA2353086
公开号：
CA2353086C
申请日:
1999.11.30
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention provides isolated nucleic acids molecules, designated PGC-1nucleic acid molecules, which encode proteins which can modulate variousadipocyte-associated activities including, for example, thermogenesis inadipocytes, e.g., brown adipocytes, and adipogenesis. The invention alsoprovides antisense nucleic acid molecules, recombinant expression vectorscontaining PGC-1 nucleic acid molecules, host cells into which the expressionvectors have been introduced, and nonhuman transgenic animals in which a PGC-1gene has been introduced or disrupted. The invention still further providesisolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1antibodies. Diagnostic, screening, and therapeutic methods utilizingcompositions of the invention are also provided.
