Compositions and methods are provided for treating a patient suffering from a disease associated with endothelial dysfunction by administering to the patient a pharmaceutical composition containing an effective amount of a synthetic collagen binding peptidoglycan. The present disclosure, in one embodiment, provides methods for treating a patient suffering from a disease associated with endothelial dysfunction. Also provided, in one embodiment, is a method for treating or inhibiting endothelial dysfunction in a patient in need thereof.Selon l'invention, des compositions et des méthodes sont mises en oeuvre pour traiter un patient souffrant d'une maladie associée à un dysfonctionnement endothélial, par administration au patient d'une composition pharmaceutique contenant une quantité efficace d'un peptidoglycane synthétique de liaison au collagène.