Provided is a combination of an epithelial sodium channel blocker and sodium chloride. The combination comprises sodium chloride in an amount of 1.5 g or more. Provided is also a method of diagnosing an increased risk of developing hypertension and/or of stratifying the risk of developing hypertension. A further method is a method of determining whether the blood pressure of a subject is sensitive to sodium intake. These methods comprise administering an epithelial sodium channel blocker and sodium chloride to the subject. After waiting for about 10 minutes or more, at least one of systolic and diastolic blood pressure of the subject is determined, and the blood pressure is compared to a control measurement or to a predetermined reference value. A temporary increase in systolic and/or diastolic blood pressure compared to the control measurement indicates a risk of a disorder, or that the blood pressure of the subject is sensitive to sodium intake. Provided is also a kit with a first container that comprises sodium chloride, but is at least essentially void of an epithelial sodium channel blocker. A second container of the kit comprises a combination of an epithelial sodium channel blocker and sodium chloride.
