Michael Kahn,Jia-Ling Teo,Michael McMillan,Yi Zhao,Yongfeng Wu
申请号：
US13895220
公开号：
US10092568B2
申请日:
2013.05.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided are: methods for treating aging or an age-related condition, symptom or disease； methods for stimulating hair growth, regrowth or pigmentation (or preventing hair loss)； methods for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth)； methods for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of a CBP/catenin (e.g., CBP/β-catenin) antagonist as disclosed, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g., CBP/β-catenin) antagonist comprises an alkyl and/or fatty acid ester derivative thereof as disclosed herein.
