LAUDON MOSHE,PELEG-SHULMAN TAL,LAUDON Moshe,PELEG-SHULMAN Tal
申请号：
SI200731333
公开号：
SI1991541T1
申请日:
2007.02.13
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
The present invention relates to a method for treating insulin resistance, neuronal loss associated with stroke, ischemia, central nervous system trauma, a central nervous system disorder, a neurodegenerative disease, the adverse consequences of the over-stimulation of excitatory amino acids, a psychiatric disease, epilepsy or other convulsive disorder, chronic pain, CMV retinitis, urinary incontinence, or for inducing anesthesia； which comprises administering to an animal or human in need thereof an effective amount of a pharmaceutical formulation comprising an effective amount of a pyrone-indole derivative of formula (I): Ar&mdash；B&mdash；Ar&prime；&emsp；&emsp；(I) wherein Ar represents an indole nucleus ring system: Ar&prime； represents an alpha-, beta- or gamma-pyrone nucleus ring system: and each of B, R1-4, and R1-2&prime； are one of the groups as defined herein.
