Compositions containing multiple different AAV stock are provided which allow for regulated expression of an immunoglobulin in a variety of tissues. Also provided is a method for regulating the dose of a pharmacologically active immunoglobulin. The method involves co-administering: (a) a first stock of recombinant AAV containing: an activation domain operably linked to expression control sequences comprising a promoter and a first nuclear localization signal and a DNA binding domain comprising a zinc finger homeodomain and two or more FK506 binding protein domain (FKBP) subimit genes, wherein a first FKBP subimit gene and a second FKBP subunit gene have coding sequences which are no more than about 85% identical to each other, said DNA binding domain being operably linked to a second nuclear localization signal and (b) a second stock of recombinant AAV comprising at least 2 to about 12 copies of a zinc finger homeodomain which are specific binding partners for the zinc finger homeodomain of the DNA binding domain, and further comprising at least one immunoglobulin expression cassette operably linked to inducible expression control sequences, such that when an effective amount of a rapamycin or rapalog is delivered transcription and expression of the immunoglobulin gene is induced.La présente invention concerne des compositions contenant un stock dAAV différent multiple pour permettre lexpression régulée dune immunoglobuline dans une diversité de tissus. Linvention concerne également un procédé de régulation de la dose dune immunoglobuline pharmacologiquement active. Le procédé implique la co-administration : (a) dun premier stock dAAV recombinant contenant : un domaine dactivation fonctionnellement lié à des séquences de régulation de lexpression comprenant un promoteur et un premier signal de localisation nucléaire et un domaine de liaison à lADN comprenant un homéodomaine en doigt de zinc et deux ou plus de deux gènes de sous-unité de domaine protéique de liaison
