PROBLEM TO BE SOLVED: To provide a hollow fiber membrane external perfusion type oxygenator capable of improving the effect of suppressing and preventing the adhesion of blood platelets.SOLUTION: The hollow fiber membrane external perfusion type oxygenator encloses in a housing gas exchanging porous hollow fiber membranes 3 comprising a hydrophobic polymer material and allows blood to flow on the outer surface side of the hollow fiber membranes and oxygen-containing gas to flow inside the hollow fiber membranes. The outer surface or outer surface layer 3a of the hollow fiber membranes forming a blood contacting section is coated with a polymer 18 having a repeating unit derived from an alkoxyalkyl (meth) acrylate. The coating of the polymer is formed on the outer surface or outer surface layer by contacting the blood flowing side of the oxygenator with a polymer containing solution with the polymer dissolved in a solvent having a solubility parameter value of 38-47.9 (MPa)1/2 and water in sequence after the hollow fiber membrane external perfusion type oxygenator is assembled.COPYRIGHT: (C)2015,JPO&INPIT【課題】血小板の粘着の抑制・防止効果を向上できる中空糸膜外部血液灌流型人工肺を提供する。【解決手段】疎水性高分子材料からなるガス交換用多孔質中空糸膜3をハウジング内に収納し、前記中空糸膜の外面側に血液が流れ、該中空糸膜の内部に酸素含有ガスが流れる中空糸膜外部血液灌流型人工肺であって、血液接触部となる前記中空糸膜の外面または外面層3aが、アルコキシアルキル(メタ)アクリレート由来の繰り返し単位を有する高分子18で被覆されてなり、前記高分子による被覆は、前記中空糸膜外部血液灌流型人工肺を組み立てた後、該人工肺の血液流通側に、溶解度パラメータ値が38~47.9(MPa)1/2である溶媒に前記高分子を溶解させた高分子含有溶液および水を順次接触させることによって、前記中空糸膜の外面または外面層に形成される、中空糸膜外部血液灌流型人工肺。【選択図】図2
