The invention relates to the treatment and the diagnosis of a group of patients bearing specific alleles of single nucleotide polymorphisms in the promoter region of the VEGFA gene. These patients are more responsive to Aflibercept and more likely to be efficiently treated by anti-VEGF therapy.本發明係關於治療及診斷攜帶VEGFA基因啟動子區域中單一核苷酸多型性(single nucleotide polymorphism)之特異性對偶基因(allele)之患者群。該等患者對阿柏西普(Aflibercept)反應更強,且更可能藉由抗-VEGF療法得到有效治療。