GRAHEK, ROK,BASTARDA, ANDREJ,JAKLIC, MIHA TOMAZ,KOCEVAR, KLEMEN,PIRC, SAMO
申请号：
CA2757988
公开号：
CA2757988C
申请日:
2010.04.06
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention belongs to the field of pharmaceutical industry andrelates to dosage forms comprising activepharmaceutical ingredients (API) such as tadalafil, simvastatin, fenofibrateand lovastatin that are practically insoluble in water,adsorbed on a carrier. Furthermore it relates to an adsorbate comprising APIbeing practically insoluble in water and to a processfor the preparation of said adsorbate with non-polar solvent (s) such aschlorinated hydrocarbon, diisopropylethes and hexane.Furthermore the invention relates to a process for the preparation of thedosage form, as well as to the use of the adsorbate for thepreparation of the dosage form. Moreover it relates to the dosage form for usein the treatment of erectile dysfunction, humanimmunodeficiency virus (HIV) infections and/or Acquired Immune DeficiencySyndrome (AIDS).
