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METHODS AND COMPOSITIONS FOR TREATING ASTHMA USING ANTIBODIES AGAINST IL-13
专利权人:
ЭББВИ ИНК. (US)
发明人:
ТРИПП Кэтрин (US)
申请号:
RU2014105288/15
公开号:
RU2014105288A
申请日:
2012.07.02
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An isolated composition comprising an anti-IL-13 antibody or antigen binding portion thereof, where, if administered to an individual at a dose of approximately 0.3 mg / kg, the antibody or antigen binding portion thereof is capable of showing: (a) the area under the curve ( AUC) equal to from about 1500 to about 2700 mcg / ml; (b) a distribution volume of from about 65 to 125 ml / kg; (c) a peak concentration (C) of from about 5 to about 8 mcg / ml; and (d) an excretion rate of from about 0.1 to about 0.2 ml / h / kg. 2. An isolated composition comprising an anti-IL-13 antibody or antigen binding part thereof, where, if administered to an individual at a dose of approximately 3 mg / kg, the antibody or antigen binding part thereof is capable of showing: (a) an area under the curve (AUC) of from about 21,000 to about 33,500 μg / ml; (b) a distribution volume of from about 55 to about 100 ml / kg; (c) a peak concentration (C) of from about 55 to about 90 μg / ml; and (d) an excretion rate of from about 0.08 to about 0.15 ml / h / kg. 3. An isolated composition comprising an anti-IL-13 antibody or antigen binding portion thereof, where, if administered to an individual at a dose of about 10 mg / kg, the antibody or antigen binding portion thereof is capable of showing: (a) area under the curve (AUC), equal to from about 75 to about 100 μg / ml; (b) a distribution volume of from about 90 to about 130 ml / kg; (c) a peak concentration (C) of from about 185 to about 250 μg / ml; and (d) the rate of excretion,1. Выделенная композиция, содержащая антитело против IL-13 или его антигенсвязывающую часть, где, если проводить внутривенное введение индивиду в дозе, равной приблизительно 0,3 мг/кг, антитело или его антигенсвязывающая часть способны демонстрировать:(a) площадь под кривой (AUC), равную от приблизительно 1500 до приблизительно 2700 мкгч/мл;(b) объем распределения, равный от приблизительно 65 до 125 мл/кг;(c) пиковую концентрацию (C), равную от приблизительно 5 до
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