Immunogenic composition

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专利权人:

グラクソスミスクライン バイオロジカルズ ソシエテ アノニム

发明人:

ボウトリュー，ドミニク,ジャーメイン，ソフィー マリー ジェーン バレンタイン,ウォールマック，ヒューグース

申请号：

JP2018020900

公开号：

JP6626521B2

申请日:

2018.02.08

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

PROBLEM TO BE SOLVED: To provide immunogenic compositions and vaccines to provide suitable immune response against Clostridium difficile.SOLUTION: The invention provides an immunogenic composition comprising a polypeptide comprising a Clostridium difficile toxin A fragment and/or a Clostridium difficile toxin B fragment, and an adjuvant comprising an immunologically active saponin fraction presented in a liposome form. An vaccine for use in treatment or prevention of Clostridium difficile disease comprising the immunogenic composition and a pharmaceutically acceptable excipient is also provided.SELECTED DRAWING: Figure 1

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