The present invention relates to a film for the oral transmucosal administration comprising therapeutically effective amount of a combination of samidorphan and buprenorphine or pharmaceutically acceptable salts thereof. The size of said film is about 0.2 to about 30 cm2. The film compositions of the invention are useful for sublingual as well as buccal applications. The invention further relates to process of preparing said film compositions as well as method of treating major depressive disorder and opioid dependence by administering such film to the subject in need thereof.
