Disclosed is a compound comprising a modified oligonucleotide consisting of 16 to 22 linked nucleosides, wherein the nucleobase sequence of the modified oligonucleotide is at least 90% complementary to miR-122 (SEQ ID NO: 1) and wherein the modified oligonucleotide comprises at least 16 contiguous nucleosides of the following nucleoside pattern I the 5’ to 3’ orientation: (R)X-NQ-NQ-NB-NB-NQ-NB-NQ-NB-NQ-NB-NB-(NZ)Y wherein each R is, independently, a non-bicyclic nucleoside or a bicyclic nucleoside； X is from 4 to 10； each NB is, independently, a bicyclic nucleoside； each NQ is, independently, a non-bicyclic nucleoside； Y is 0 or 1； and NZ is a modified nucleoside or an unmodified nucleoside.
