PROBLEM TO BE SOLVED: To provide a new therapeutic composition for treating cancers.SOLUTION: The invention relates to therapeutic compositions comprising binding agents which specifically bind to tumor-associated MUC-1 and reduce or prevent their effects in cancer. More particularly, the invention relates to therapeutic compositions which comprise a binding agent specifically binding to an epitope comprising both peptide and carbohydrate on such tumor-associated MUC-1. The invention further provides methods for therapeutically treating a mammal bearing a tumor comprising administering to the mammal an effective amount of such therapeutic composition.COPYRIGHT: (C)2012,JPO&INPIT【課題】癌治療における新規な治療組成物の提供。【解決手段】腫瘍関連MUC-1に特異的に結合し、癌におけるそれらの効果を低下または阻止する結合剤を含む治療組成物。特に、このような腫瘍関連MUC-1上のペプチドと炭水化物の両方を含むエピトープに特異的に結合することができる結合剤を含む治療組成物。さらに、このような治療組成物の有効量を哺乳動物に投与することを含む、腫瘍を保有する哺乳動物を治療的に処置する方法。【選択図】なし
