The present disclosure relates to compositions and methods for contraception that also enhance the efficacy of microbicides. Such compositions serve the dual purpose of preventing pregnancy and lessening the risk of spreading sexually transmitted diseases. More specifically, the compositions and methods relate to contraceptive microbicides optionally in combination with an antiviral agent, said compositions comprising a matrix forming compound and an acidic carrier that enhance the efficacy of the contraceptive microbicide and optionally the antiviral agent.