Provided is a topical dermatological composition having an inhibitory effect on collagen and fibronectin production. This topical dermatological composition contains pentosan polysulfate and/or a salt thereof as an active ingredient. This topical dermatological composition is useful in the prevention and/or treatment of conditions such as hypertrophic scars, scars/keloids, muscular torticollis, and nodular eruptions, and exhibits a better inhibitory effect on collagen and fibronectin production than mucopolysaccharide polysulfate (MPS).本發明提供一種具有對膠原蛋白及纖網蛋白產生之抑制作用之皮膚外用組成物。本發明之皮膚外用組成物含有戊聚醣多硫酸酯（pentosan polysulfate）及/或其鹽作為有效成分。該皮膚外用組成物對於預防及/或治療肥厚性瘢痕、瘢痕/蟹足腫、肌性斜頸、結節性癢疹等疾病有用，顯示出優於多硫酸化黏多醣（MPS）之膠原蛋白及纖網蛋白產生抑制作用。
