Hille Thomas,Wauer Gabriel,Smith Kevin John,Mundin Gillian Elizabeth,Johnson Helen Elizabeth
申请号：
NZ62653512
公开号：
NZ626535A
申请日:
2012.12.12
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Provided is a transdermal therapeutic system comprising: A) a buprenorphine-impermeable backing layer, and B) a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising: a) at least one polymer-based pressure-sensitive adhesive, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, and c) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid and linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture, and the carboxylic acid buprenorphine mixture forms dispersed deposits in the said pressure-sensitive adhesive, wherein said buprenorphine-containing pressure-sensitive adhesive layer is the skin contact layer. The polymer-based adhesive is based on polysiloxanes or polyisobutylenes. The transdermal system is used for the manufacture of a medicament for the treatment of pain where the system is applied to the skin for 168h aka 7 days aka 1 week.
