Peter John Bonitatibus, Jr.,Amit Mohan Kulkarni,Andrew Soliz Torres,Ying Zhou,Chiaki Treynor,Daniel Eugene Meyer
申请号：
US12057650
公开号：
US08246932B2
申请日:
2008.03.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.
