Papeo, Gianluca Mariano Enrico,Bertrand, Jay Aaron,Cervi, Giovanni,Forte, Barbara,Lupi, Rosita,Montagnoli, Alessia,Scolaro, Alessandra,Zuccotto, Fabio,Orsini, Paolo,Posteri, Helena
申请号：
AU2010251112
公开号：
AU2010251112A2
申请日:
2010.05.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
There are provided substituted isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly (ADP- ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. A screening method for the identification of compounds capable of binding several PARP proteins, as well the probes used in such method, are further objects of the invention.
