A pharmacological powder for inhalation comprising fine particles of a drugand particles of a force-controlling agent, wherein the particles of saidforce-controlling agent are disposed on the surface of the active particles aseither a particulate coating, or as a continuous or discontinuous film. Thepowder may further comprise particles of a carrier material for supporting thedrug particles. The force-controlling agent may be selected from: amino acids,peptides and polypeptides having a molecular weight of from 0.25 to 1000 KDa；phospholipids； titanium dioxide； aluminium dioxide； silicon dioxide； starch；and salts of fatty acids. Also disclosed is a method of making such a powderfor inhalation comprising mixing a force-controlling agent with particles ofone or more pharmacologically active materials to obtain a mixture in whichthe particles of said force-controlling agent are disposed on the surface ofthe active particles as either a particulate coating, or as a continuous ordiscontinuous film. The mixing step may be achieved by sieving, mixing orblending, micronising and/or co-micronising the particles of one or morepharmacologically active material and particles of force-controlling agents.
