STEROID ALKALOIDS AND USES THEREOF AS ANTIMICROBIAL AGENTS AGAINST ELECTRON TRANSPORT-DEFICIENT MICROBES AND AS POTENTIATORS FOR ANTIMICROBIAL AGENTS AGAINST PATHOGENIC BACTERIA
Gabriel Mitchell;Felix Chagnon;Kamal Bouarab;Isabelle Guay;Eric Marsault;François Malouin;Simon Boulanger
发明人:
François Malouin,Gabriel Mitchell,Kamal Bouarab,Eric Marsault,Felix Chagnon,Simon Boulanger,Isabelle Guay
申请号：
US13984991
公开号：
US20140018312A1
申请日:
2012.02.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention includes novel compounds based on the tomatidine skeleton as well as composition comprising these compounds alone and in combination with known compounds, which exhibit antimicrobial activity against extracellular or intracellular electron transport-deficient microbes and/or increase the antimicrobial activity of aminoglycoside antibiotics against their targets, and which are useful as antibacterial agents for treatment or prophylaxis of monomicrobiotic or polymicrobic bacterial infections or for the reduction of antibiotic resistance development in animals or in humans, or for use as antiseptics or agents for sterilization or disinfection.
