Stephanie Hachtel,Heinrich Christian Englert,Uwe Gerlach,Heinz Goegelein,Holger Heitsch,Karl-Heinz Lehr,Stefania Pfeiffer-Marek
申请号：
US11761565
公开号：
US08586612B2
申请日:
2007.06.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to piperidinesulfonylureas and piperidinesulfonylthioureas of formula I,in which A, X, R(1), R(2) and R(3) have the meanings indicated in the claims. The compounds of formula I are valuable active pharmaceutical ingredients which show in particular an inhibiting effect on ATP-sensitive potassium channels of the cardiac muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, cardiomyopathies or reduced contractility of the heart or for the prevention of sudden cardiac death. The invention further relates to processes for preparing the compounds of formula I, their use and pharmaceutical compositions comprising them.
