Caroline J. Dimech;Adriaan Allart Stoop;Rudolf Maria De Wildt;Steve Holmes
发明人:
Caroline J. Dimech,Adriaan Allart Stoop,Rudolf Maria De Wildt,Steve Holmes
申请号：
US13387376
公开号：
US20120129778A1
申请日:
2010.07.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis, liver fibrosis, including cirrhosis and chronic hepatitis, rheumatoid arthritis, ocular disorders, or fibrosis of the skin, including keloid of skin, and kidney such as nephritis, kidney fibrosis and nephrosclerosis, and a vascular condition, such as restenosis.
