DEShAM Ehlizabet Benedikt Daniel' (DE),ДЕШАМ Элизабет Бенедикт Даниель (DE),ShMIDT Karsten (DE),ШМИДТ Карстен (DE),ALLAN Mark (DE),АЛЛАН Марк (DE),DESHAM EHLIZABET BENEDIKT DANIEL,SHMIDT KARSTEN,ALLAN MARK
申请号：
RU2009100919/15
公开号：
RU0002445089C2
申请日:
2007.06.13
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention concerns veterinary science. A pharmaceutical composition in the form of a water suspension containing benzimidazole carbamate particles, surfactant polysorbate and a pharmaceutically acceptable carrier, where at least 90% of the benzimidazole carbamate particles have a mean particle size is less than 450 nm. A method for preparing a pharmaceutical composition comprises dispersion of the benzimidazole carbamate particles in a mixture containing the pharmaceutically acceptable carrier and the surfactant polysorbate； and mechanical size reduction of the benzimidazole carbamate particles to an effective mean particle size less than 450 nm. A method for producing therapeutic drinking water involves making said pharmaceutical composition, adding the pharmaceutically acceptable carrier to the composition and adding the end product to drinking water. Therapeutic drinking water contains 10 to 150 particles/mil. benzimidazole carbamate particles where at least 90% of the benzimidazole carbamate particles have the mean particle size less than 450 nm. Using said pharmaceutical composition for preparing a drug for control of parasites in animals.EFFECT: invention provides stability of the suspension over 24 hours and enables to distribute therapeutic drinking water with homogenous distribution of the drug along the system tube designed for drinking water supply, and respectively maintained dose accuracy for all animals.5 cl, 12 exИзобретение относится к ветеринарии. Фармацевтическая композиция в форме водной суспензии содержит частицы карбамата бензимидазола, поверхностно-активное вещество полисорбат и фармацевтически приемлемый носитель, где по меньшей мере 90% частиц карбамата бензимидазола имеют средний размер частиц менее чем 450 нм. Способ получения фармацевтической композиции включает испергирование частиц карбамата бензимидазола в смеси, содержащей фармацевтически приемлемый носитель и поверхностно-активное вещество п
