The invention discloses a drug composite for preventing diabetic nephropathy and application to preparing medicines for treating diabetes-related complications the drug composite is composed of one or two of active ingredients-calycosin and calycosin-7-0-D-glucopyranpside, and a carrier which is acceptable in pharmacy the content of the active ingredients is 0.1-99.5 percent the drug composite is mainly applied to preparing medicines for treating diabetes-related complications the drug composite has obvious prevention function to the diabetic nephropathy, the usage is convenient, the quality is controllable, so as to provide new drug candidate for treatment.
