WIDDISON, WAYNE C.,Widdison, Wayne C.,CHARI, RAVI V.J.,Chari, Ravi V.J.
申请号：
HRP20160046
公开号：
HRP20160046T1
申请日:
2016.01.14
申请国别(地区):
HR
年份:
2016
代理人:
摘要：
New thiol and disulfide-containing maytansinoids bearing a substitution on the ±-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
