The Brigham and Women's Hospital; Inc.;The Brigham and Womens Hospital
发明人:
Freedman, Benjamin S.,Bonventre, Joseph V.
申请号：
AU2016318114
公开号：
AU2016318114A1
申请日:
2016.09.02
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Human pluripotent stem cells (hPSCs) have dual value as microphysiological laboratory models and regenerative therapeutics. hPSCs are epithelial cells, but the extent to which hPSCs and descendant epithelia can reconstitute lineage-specific functions remains poorly understood. Here the Inventors show that hPSCs in three-dimensional cultures and their differentiated descendants can functionally recapitulate tissue-specific epithelial morphogenesis, physiology, and disease.
