LACHANCE, NICOLAS,LECLERC, JEAN-PHILIPPE,LI, CHUN SING,MORADEI, OSCAR MIGUEL
申请号：
ES10743365
公开号：
ES2545864T3
申请日:
2010.02.16
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound of structural formula I: ** Formula ** or a pharmaceutically acceptable salt thereof； wherein A is selected from the group consisting of: ** Formula ** g is a single bond or a double bond； J and K are each independently selected from the group consisting of: S, O, NH, CH and CH2, in which each NH is unsubstituted or substituted with Rg, and in which each CH and CH2 are unsubstituted or substituted with R2, with the proviso that when g is a single bond at least one of J and K is CH2 without replacing or substituted with R2, and also with the proviso that when g is a double bond then both J and K are CH； ** Formula ** L and M are each independently selected from the group consisting of: S, O, NH and CH2, in which each NH is unsubstituted or substituted with Rg, and in which each CH2 is unsubstituted or substituted with R2； T, U, V and W are each independently selected from N and CH, in which each CH is unsubstituted or substituted with R3, with the proviso that at least two of T, U, V and W are CH； X is CH2, in which CH2 is unsubstituted or substituted with R2； And it is independently selected from the group consisting of: O, NH and CH2, in which each NH is unsubstituted or substituted with Rg, and in which each CH2 is unsubstituted or substituted with R2； Z is independently selected from the group consisting of: S, S (O), S (O) 2, O, NH and CH2, in which each NH is unsubstituted or substituted with Rg, and in which each CH2 is unsubstituted or substituted with R2； B is a 5-membered heteroaryl ring containing 1, 2 or 3 heteroatoms selected from NH, O and S, in which any CH is unsubstituted or substituted with a substituent selected from Ra, and in which any NH is unsubstituted or substituted with a substituent selected from Rb； each R1 is independently selected from the group consisting of: hydrogen, halogen and C1-3alkyl, in which alkyl is unsubstituted or substituted with one to three substituents independently selected from halogen and hydroxy； each R2 is
