Takeshi KUBOYAMA,Kaori YAGI,Tomoyuki NAOI,Tomohiro ERA
申请号：
US14206193
公开号：
US20140294978A1
申请日:
2014.03.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides a cationic lipid and the like. The cationic lipid is for delivering a medicament containing a cationic lipid which facilitates the introduction of a nucleic acid into a cell or the like, and is represented by formula (I).In the formula, R1 is linear or branched alkyl, alkenyl, or alkynyl, each having 8 to 24 carbon atoms,R2 is linear or branched alkyl, alkenyl, or alkynyl, each having 8 to 24 carbon atoms, or alkoxyethylene, alkoxypropylene, alkenyloxyethylene, alkenyloxypropylene, alkynyloxyethylene, or alkynyloxypropylene,R3 and R4 may be the same or different, and are each alkyl having 1 to 3 carbon atoms or are combined together to form alkylene having 2 to 6 carbon atoms, or R3 and R5 are combined together to form alkylene having 2 to 6 carbon atoms,R5 is a hydrogen atom, alkyl having 1 to 6 carbon atoms, alkenyl having 3 to 6 carbon atoms, amino, monoalkylamino, hydroxy, alkoxy, carbamoyl, monoalkylcarbamoyl, dialkylcarbamoyl, or the like, or is combined together with R3 to form alkylene having 2 to 6 carbon atoms,X is alkylene having 1 to 6 carbon atoms, andY is a single bond, alkylene having 1 to 6 carbon atoms, or the like.
