Covadonga Alonso Martí,Bruno Hernaez De La Plaza,José Angel Martinez Escribano
申请号：
US12739415
公开号：
US20120289459A1
申请日:
2008.10.20
申请国别(地区):
US
年份:
2012
代理人:
摘要：
New antiviral peptides interfering the binding of the virus to DLC8. A high number of pathogenic agents of viral origin use the dynein based intracellular transport machinery at some point of their infective cycle. The present invention consists of a new antiviral therapy consisting in the inhibition of viral infections produced by those virus that use the dynein system by mechanisms of interference mainly by preventing the interaction between the viral protein and the cellular DLC8 protein. The present invention discloses for the first time the blocking of the function of this interaction by peptides whose sequence comprises or consists of the totality or a partial sequence of the viral protein corresponding to the binding domain with DLC8.
