Veverka, Karen, A.,Dalton, James T.,MILLER, Duane D.,Kim, Juhyun
申请号：
DK10075691
公开号：
DK2289872T3
申请日:
2005.06.07
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
Selective androgen receptor modulator (SARM) compounds having the formula (II): wherein Z XisO； is NO 2 , CN, COR, or CONHR； Y is I, CF 3 , CH 3 , H, Br, Cl, F or Sn(R) 3 ； R is an alkyl, aryl, phenyl, alkenyl, haloalkyl, haloalkenyl, halogen or OH； and Q is C N . These compounds may be used in treating a subject having: a bone-related disorder, such as osteoporosis, osteopenia, increased bone resorption, bone fracture, bone frailty, loss of bone mineral density (BMD)； a muscle wasting disorder, such as muscular dystrophy, a muscular atrophy, X-linked spinal-bulbar muscular atrophy (SBMA), a cachexia, sarcopenia, or a cardiomyopathy； hypercholesterolemia； obesity or diabetes associated with a metabolic syndrome such as a hormonal imbalance, disorder, or disease； or may be used in: promoting or speeding recovery following a surgical procedure； and promoting or suppressing spermatogenesis in a male subject.
