University of Washington;Pacific Lutheran University
发明人:
Andrew J. Boydston,Neal A. Yakelis,Derek C. Church
申请号：
US15405988
公开号：
US20170202874A1
申请日:
2017.01.13
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Multivalent scaffolds configured to facilitate drug release upon exposure to a stimulus, such as heat, or light, are described herein. The multivalent scaffolds are covalently bound to a moiety that is susceptible to decomposition upon exposure to stimulus. The moiety releases HNO upon decomposition. In some embodiments, the moiety is in turn linked to an agent to be delivered, such as a therapeutic agent, which is released from the multivalent scaffolds when the moiety decomposes. In some embodiments, the moiety is a 1,2-oxazine moiety. In some embodiments, the multivalent scaffold is a polymer. A plurality of 1,2-oxazine moieties can be covalently bound as side chains to the backbone of the polymer.
