Azcarate-Peril, Andrea,Buck, B. Logan,Klaenhammer, Todd R.,Altermann, Eric
申请号：
AU2006236629
公开号：
AU2006236629B2
申请日:
2006.04.14
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Methods and compositions are provided which improve the adhesion of a bacteria totarget substrates and/or improve the stress tolerance of a bacteria. Methods compriseexposing bacteria to adhesion adaptive conditions and thereby increasing theadhesion activity and/or stress tolerance of the bacteria. Further provided arebacteria having a modulated production of autoinducer-2. Compositions includerecombinant bacteria expressing nucleic acid molecules involved in the pathwayof autoinducer-2 production. Further provided are autoinducer-2-related fusionproteins, antigenic peptides, antibodies, and vectors. Methods of screening compoundsor environmental conditions which will stimulate the production of autoinducer-2and/or produce an adhesion adaptive response are further provided, as are variousmethods of use for the bacteria having increased adhesion and/or stress tolerance.
