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Modified small interfering RNA molecules and methods of use
专利权人:
Jang Han;Michael Houghton
发明人:
Jang Han,Michael Houghton
申请号:
US11664008
公开号:
US08138161B2
申请日:
2005.09.30
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides double-stranded RNA molecules that mediate RNA interference in target cells, preferably hepatic cells. The invention also provides double-stranded RNA (dsRNA) molecules that are modified to be resistant to nuclease degradation, which inactivates a virus, and more specifically, hepatitis C virus (HCV). The invention also provides a method of using these modified RNA molecules to inactivate virus in mammalian cells and a method of making modified small interfering RNAs (siRNAs) using human Dicer. The invention provides modified RNA molecules that are modified to include a dsRNA or siRNA wherein one or more of the pyrimidines in the RNA molecule are modified to include 2′-Fluorine. The invention also provides dsRNA or siRNA in which all pyrimidines are modified to include a 2′-Fluorine. The invention provides that the 2′-Fluorine dsRNA or siRNA molecule is further modified to include a two base deoxynucleotide “TT” sequence at the 3′ end of the molecule.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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