PARK, Dong Hui; William Abrão;SAAD, William Abrão;SAAD
发明人:
SAAD, William Abrão,PARK, Dong Hui
申请号:
BRBR2016/050220
公开号:
WO2018/039755A1
申请日:
2016.09.05
申请国别(地区):
BR
年份:
2018
代理人:
摘要:
The present invention relates to compositions for preventing or treating the symptoms of infections caused by Flavivirus, such as Dengue. The compositions comprise a combination of a zinc compound, which can be chelated and/or non-chelated with the flavonoid quercetin or analogues and derivatives thereof, with other components also being optionally included in the formulation according to the recommendation, age group, form of presentation, existing conditions and weight. Antiviral activity is achieved by means of the synergistic effect of quercetin and zinc, which act via various mechanisms of action, preventing the virus from creating mechanisms of resistance. The present invention falls within the field of pharmacy, notably where said compositions can be produced for HUMAN AND ANIMAL use in the following DOSAGE FORMS: ORAL in capsules, which can be hard, soft or gelatinous; tablets, which can be coated or uncoated, in the form of dragées, film-coated and also dispersible; syrups; solutions; suspensions; emulsions and gel solutions. INJECTABLES: ampoule, vial-ampoule, physiological and glucose saline. TOPICAL: ointment, cream, paste, powder and gel, and micro- and nanostructures can also be used. INHALATIONAL: spray and nebulizer.La présente invention concerne des compositions pour prévenir ou traiter les symptômes infectieux causés par flavivirus, notamment la dengue. Ces compositions comprennent une combinaison d'un composé de zinc pouvant être chélaté et/ou non chélaté avec le flavonoïde quercétine ou ses analogues et dérivés, d'autres composants pouvant en outre entrer dans la formulation selon l'indication, la tranche d'âge, la forme de présentation, les pathologies existantes et le poids. L'activité antivirale est atteinte au moyen de l'effet synergique de la quercétine et du zinc, qui agissent à travers différents mécanismes d'action, empêchant que le virus développe des mécanismes de résistance. La présente invention relève du domaine de la pharmacie, et p