Useful compositions for treating disorders related to KIT

• 收藏
• 分享

专利权人:

Blueprint Medicines Corporation

发明人:

ZHANG, Yulian,HODOUS, Brian,KIM, Joseph,WILSON, Kevin,WILSON, Douglas

申请号：

ES14799576

公开号：

ES2683127T3

申请日:

2014.10.15

申请国别(地区):

ES

年份:

2018

代理人:

摘要：

A compound of Formula II: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: Ring A is selected from monocyclic or bicyclic aryl, monocyclic or bicyclic heteroaryl, cycloalkyl and heterocyclyl； Z is selected from C1-C6 alkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heteroaryl, monocyclic or bicyclic heterocyclyl, and monocyclic or bicyclic heterocyclyl alkyl, wherein each of C1-C6 alkyl, cycloalkyl monocyclic or bicyclic aryl, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heteroaryl, monocyclic or bicyclic heterocyclyl, and monocyclic and bicyclic heterocyclyl alkyl is independently substituted with 0-5 RC occurrences； L is selected from a bond, - (C (R2) (R2)) m-, - (C2-C6 alkynylene) -, - (C2-C6 alkenylene) -, - (C1-C6 haloalkylene) -, - (heteroalkylene C1-C6) -, - (C1-C6 hydroxyalkylene) -, -C (O) -, -O-, -S-, -S (O), -S (O) 2-, -N (R2) - , -O- (C1-C6 alkylene) -, - (C1-C6 alkylene) -O-, -N (R2) -C (O) -, -C (O) -N (R2) -, - (alkylene C1-C6) -N (R2) -, -N (R2) - (C1-C6 alkylene) -, - N (R2) -C (O) - (C1-C6 alkylene) -, -C (O) - N (R2) - (C1-C6 alkylene) -, -N (R2) -S (O) 2-, -S (O) 2-N (R2) -, -N (R2) -S (O) 2 - (C1-C6 alkylene) -, and -S (O) 2-N (R2) - (C1-C6 alkylene) -； each RA and RB is independently selected from C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclyl, halo, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 heteroalkyl, monocyclic or bicyclic aralkyl, -N (R2) (R2), cyano, and - OR2； each RC is independently selected from C1-C6 alkyl, C1-C6 alkynyl, halo, C1-C6 heteroalkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 hydroxyalkyl, cycloalkyl, monocyclic or bicyclic aryl, monocyclic or bicyclic aryloxy, monocyclic or bicyclic aralkyl, monocyclic or bicyclic heterocyclyl, monocyclic or bicyclic heterocyclylalkyl, nitro, cyano, -C (O) R2, -OC (O) R2, -C (O) O2, -SR2, -S (O) 2R2, -S (O) 2-N (R2) (R2), - (C1-C6 alkylene) -S (O) 2-N (R2) (R2), -N (R2) (R2), -C (O ) -N (R2) (R2), -N

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/