Gombert, Frank,Vrijbloed, Wim,Robinson, John Anthony,Dias, Ricardo,Obrecht, Daniel,Srinivas, Nityakalyani,Demarco, Steve J.
申请号：
AU2007204547
公开号：
AU2007204547B2
申请日:
2007.01.15
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Template-fixed β-hairpin peptidomimetics of the general formula (I)wherein Z is a template-fixed chain of 12 α-amino acid residues which,depending on their positions in the chain (counted starting firom the N-terminalamino acid) are Gly, or Pro, or of certain types which, as the remaining Symbolsin the above formula, are defined in the description and the claims, and saltsthereof, have the property to selectively inhibit the growth of or to kill microorganismssuch as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs,cosmetics, medicaments or other nutrient-containing materials, or as medicamentsto treat or prevent infections. These β-hairpin peptidomimetics canbe manufactured by processes which are based on a mixed solid- and Solution phasesynthetic strategy.
