Harbin Veterinary Research Institute; Chinese Academy of Agricultural Sciences
发明人:
申请号：
EP17872552.9
公开号：
EP3543332A1
申请日:
2017.11.20
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
A temperature-sensitive attenuated FMDV strain, construction method and applications thereof. The construction method of the temperature-sensitive attenuated FMDV strain is as follows. Mutating a cytosine on K region loop of IRES domain 4 of an FMDV genome to a guanine or an adenine to obtain the temperature-sensitive attenuated FMDV strain, or replacing a K region of IRES domain 4 of an FMDV genome with a K region of IRES domain 4 of a bovine rhinovirus genome to obtain the temperature-sensitive attenuated FMDV strain.
