Whitehead Institute for Biomedical Research;Trustees of Tufts College
发明人:
Harvey Lodish,Nai-Jia Huang,Novalia Pishesha,Hidde L. Ploegh,Charles Shoemaker
申请号：
US16641203
公开号：
US20200206269A1
申请日:
2018.08.22
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Multi-step methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express fusion proteins comprising an antigen binding protein which allows the red blood cell to bind a toxin or an antigen of a pathogen. Also described herein are methods for neutralizing a toxin or pathogen in a subject by administering enucleated red blood cells that express any of the fusion proteins provided herein.
