David AMANTINI,Milan MESIC,Gordon SAXTY,Tanja POLJAK,Ines VUJASINOVIC,Dinko ZIHER,David WITTY,Karl Richard GIBSON
申请号：
US16632202
公开号：
US20200165259A1
申请日:
2018.07.12
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to pyrrolopyrimidine compounds according to Formula I and their use in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases. In a particular aspect, the present compounds are ASK inhibitors, particularly ASK1 inhibitors. The present invention also provides methods for the production of a compound of the invention, pharmaceutical compositions comprising a compound of the invention, the use of the compounds in the prophylaxis and/or treatment of pain, inflammatory conditions, cardiovascular diseases, neurodegenerative diseases, neurological diseases, complications of type I diabetes, cancer and/or fibrotic diseases.
