A shield seals out moisture over a portion of a wearers limb. The shield may be used to protect chronic Intravenous (IV) sites preventing moisture from reaching the IV site and provides a moisture tight compartment for carrying personal items during aquatic activities. The shield is made of a thermoplastic elastomer material which freely stretches and includes two opposing very small entry openings which stretch to form collar regions at each stretched opening providing an area versus a line of contact between the shield and skin thereby sealing out moisture. The improved sealing of the present invention allows many activities previously denied to patients. The shield is preferably generally spherical but may be elliptical, football shaped, oval, or other shapes and may have one closed end or multiple openings for fingers or toes.