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Spiro compounds having stearoyl-CoA desaturase action
专利权人:
Takahiko Taniguchi
发明人:
Takahiko Taniguchi,Kenichi Miyata,Osamu Kubo
申请号:
US12449320
公开号:
US08575167B2
申请日:
2008.02.05
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention aims to provide a novel SCD inhibitor.The present invention relate to SCD inhibitor comprising A compound represented by the formula (I)whereinR is an optionally substituted cyclic group or an optionally substituted carbamoyl group, provided that R is not an optionally substituted 7-pyrido[2,3-d]pyrimidyl groupring A is an optionally further substituted pyridazine ringR1, R2, R3, R4, R11, R12, R13 and R14 are each independently a hydrogen atom or a substituent, or R1 and R11 in combination, R2 and R12 in combination, R3 and R13 in combination, or R4 and R14 in combination optionally form an oxo group, or R2 and R4 in combination optionally form a bond or an alkylene cross-linkagem and n are each independently an integer of 0 to 2ring B is an optionally substituted ring, provided that the two atoms constituting ring B, which are adjacent to the spiro carbon atom, are not oxygen atoms at the same time,or a salt thereof, or a prodrug thereof.
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