Manh-Dan Ngo,Katherine Gomes Truncale,Jeffrey S. Cartmell,Carina Syring,Rudiger Von Versen
申请号：
US12772602
公开号：
US08557581B2
申请日:
2010.05.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps:(1) isolating from a suitable donor a desired soft tissue sample of the biological material(2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water(3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same(4) processing the tissue by cutting the tissue to size and perforating the tissue and(5) dipping the tissue in 70% ethanol and packaging the tissue.
